PrV

PrV UL27

Predicted structure model: AlphaFold 2.

The model was generated using AlphaFold 2.

Predicted Structure (AlphaFold 2)
Predicted Aligned Error (PAE) Click image to open full size
Predicted Aligned Error (PAE)
Structural Homologs
Virus Protein Uniprot pTM
HSV-1 UL27 P10211 0.50
HSV-2 UL27 P08666 0.49
VZV ORF31 P09257 0.49
MDV MDV040 Q77MS3 n/a
PrV UL27 G3G951 n/a
HCMV UL55 F5HB53 0.48
RCMV E55 K7YA28 n/a
HHV-6A U39 P28864 0.52
HHV-6B U39 P36320 0.53
HHV-7 U39 O56280 0.53
EBV BALF4 P03188 0.48
KSHV ORF8 F5HB81 0.49
MHV68 ORF8 Q98336 n/a

This page uses Mol* for molecular visualization, with JSmol as a fallback when WebGL is unavailable.

Predictions were run with Colabfold by the Steinegger lab:
Mirdita M, Schutze K, Moriwaki Y, Heo L, Ovchinnikov S, Steinegger M. "ColabFold: Making protein folding accessible to all". Nature Methods (2022) doi: 10.1038/s41592-022-01488-1

Foldseek is developed by the Steinegger lab:
van Kempen M, Kim S, Tumescheit C, Mirdita M, Soding J, and Steinegger M. "Fast and accurate protein structure search with Foldseek". Nature Biotechnology (2023) doi: 10.1038/s41587-023-01773-0

Alphafold2 was developed by Deepmind:
Jumper et al. "Highly accurate protein structure prediction with AlphaFold." Nature (2021) doi: 10.1038/s41586-021-03819-2

Signal peptide predictions were performed with DeepTMHMM
Jeppe Hallgren, Konstantinos D. Tsirigos, Mads Damgaard Pedersen, Jose Juan Almagro Armenteros, Paolo Marcatili, Henrik Nielsen, Anders Krogh, Ole Winther. "DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks." bioRxiv (2022) doi: 10.1101/2022.04.08.487609

AlphaFold3 models were generated through the Alphafold Server, which uses Google DeepMind's AlphaFold technology
Abramson J, et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature (2024). doi: 10.1038/s41586-024-07487-w