AlphaFold Multimer predicted interaction networks across human herpesviruses. Explore and compare multiple PPI datasets.
Select one or more datasets from the dropdown. Common shows interactions present in all selected datasets. Unique A vs B shows interactions in A but not in B.
This page displays LocalColabFold/AlphaFold Multimer predicted protein-protein dimer interactions in the herpesviruses HSV-1 strain 17 (UP000009294), HCMV strain Merlin (UP000000938), KSHV strain GK18 (UP000000942) and VZV strain Dumas (UP000008770).
Data status: Interactions shown on this page were extracted from source databases on November 6, 2025.
Soh, T., & Bosse, J. (2024). HerpesFolds: All-versus-all protein interaction network [Data set]. Zenodo. https://doi.org/10.5281/zenodo.12517508
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Keep in mind that some proteins, such as gB, will need to form high-order oligomers to function. Therefore, the dimeric predictions displayed here might inform on interfaces but they might not represent functional units.
Click and drag to move around, use the mouse wheel to zoom, click nodes to explore proteins and click on edges to explore interactions.
Use the selection board above to generate and compare networks. Select one or more datasets in "Include" (Group A). Common shows interactions present in every selected file of Group A (intersection). Unique A vs B shows interactions present in all files of A but in none of the files in B.
Reference for labels limits labels to the chosen base virus so that proteins from different datasets are mapped to the same identifiers; choose Auto to use the first file in A.
Each virus type has been assigned a unique color:
HSV-1 HSV-2 VZV HCMV HHV-6A HHV-6B HHV-7 EBV KSHV HSV-1-cross-link HSV-1-Topf
This is a project in cooperation with the Topf lab at CSSB.
This page uses David Sehnal, Sebastian Bittrich, Mandar Deshpande, Radka Svobodová, Karel Berka, Václav Bazgier, Sameer Velankar, Stephen K Burley, Jaroslav Koča, Alexander S Rose: Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures, Nucleic Acids Research, 2021; for molecular visualization, with JSmol as a fallback when WebGL is unavailable.
Predictions were run with LocalColabFold on the DESY compute cluster.
See also:
The network was created using cytoscape.js, a Graph theory library for visualization and analysis, which was developed by Franz M, Lopes CT, Huck G, Dong Y, Sumer O, Bader GD at the University of Toronto https://js.cytoscape.org/
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| Dataset | Weight Column |
|---|---|
| HerpesPPIs_Soh-2024: doi.org/10.1038/s41467-024-54668-2 | ipTM |
| HSV-1_Cross-Link_Bogdanow-2025: doi.org/10.1038/s41467-025-61618-z | XLinks |
| HCMV_Cross-Link_Bogdanow-2023: doi.org/10.1038/s41564-023-01433-8 | XLinks |
| HVINT2_Duran-2019: hvint2.topf-group.com • doi.org/10.1128/mSystems.00295-19 | Confidence Score |
| IntAct: ebi.ac.uk/intact • doi.org/10.1093/nar/gkab1006 | MI Score |
| MINT: mint.bio.uniroma2.it • doi.org/10.1093/nar/gkr930 | MI Score |
| HSV-1 LUCIA: • | ratio / p-value |