AdenoPPIs

This page displays LocalColabFold/AlphaFold Multimer predicted protein-protein dimer interactions in different Adenoviruses.

Click and drag to move around, use the mouse wheel to zoom, click nodes to explore proteins and click on edges to explore interactions.

Clicking on the buttons selects the virus interactome. When more than one button is selected, the conserved interactions between the viruses are displayed. The unique button displays interactions uniquely found in one virus or interactions uniquely conserved between more viruses.

The table on the right lists all interactions. Clicking on the column headers will sort the table. Clicking on a node filters the table to show only interactions with that protein. Clicking in the background of the graph deselects the protein and all interactions are shown again. The links in the protein source and target columns will open the prediction website for the monomer with the scores and 3D models. The link in the ipTM column will open the PPI website with the scores and predicted 3D models.

The size (weight) of the connections encodes how well an interaction was predicted by AlphaFold 2. A thicker connection indicates a more likely interaction than a thinner one. Thickness is calculated from AlphaFold Multimer's ipTM value. Only interactions with an ipTM value greater than 0.47 are shown. The ipTM values have been normalized and scaled from a 0.6-1.00 to a -1-8 scale for easier visual interpretation.